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Mol Cell Biochem. 1989 Feb 21;85(2):103-14.

The La antigen shuttles between the nucleus and the cytoplasm in CV-1 cells.

Author information

1
Institut für Physiologische Chemie, Universität, Mainz, FRG.

Abstract

Recently we established a monoclonal antibody against the La-protein (Bachmann et al., Proc. Natl. Acad. Sci. USA, 83, 7770, 1986). The antibody gives a nuclear speckled type staining and, in addition, a perinuclear cytoplasmic staining on cultured cells in immunofluorescence microscopy. After inhibition of RNA synthesis the La-protein is transported into the cytoplasm. After prolonged inhibition it returns into the nucleus forming large growing speckles. The transport into the nucleus apparently depends on glycosylation.

PMID:
2657384
DOI:
10.1007/bf00577106
[Indexed for MEDLINE]

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