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Complement Ther Clin Pract. 2015 Nov;21(4):223-8. doi: 10.1016/j.ctcp.2015.08.001. Epub 2015 Aug 12.

A pilot randomized double-blind placebo-controlled trial on topical chamomile (Matricaria chamomilla L.) oil for severe carpal tunnel syndrome.

Author information

1
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran; Department of Traditional Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
2
Department of Traditional Persian Medicine, School of Traditional Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Essence of Parsiyan Wisdom Institute, Traditional Medicine and Medicinal Plant Incubator, Shiraz University of Medical Sciences, Shiraz, Iran.
4
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
5
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: kayhomayouni@gmail.com.
6
Pharmaceutical Sciences Research Center and Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Research Office for the History of Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

OBJECTIVE:

To assess the effectiveness of standardized topical Chamomile (Matricaria chamomilla L.) oil in patients with severe carpal tunnel syndrome, as a complementary treatment.

METHOD:

A pilot randomized double-blind placebo-controlled trial was conducted. Twenty six patients with documented severe carpal tunnel syndrome were treated in two parallel groups with a night splint plus topical chamomile oil or placebo. They were instructed to use their prescribed oil for 4 weeks, twice daily. Symptomatic and functional status of the patients and their electrodiagnostic parameters were evaluated when enrolled and after the trial period, as our outcome measures.

RESULTS:

A significant improvement of symptomatic and functional status of patients in the chamomile oil group was observed (p = 0.019 and 0.016, respectively) compared with those in the placebo group. However, electrodiagnostic parameters showed no significant changes between the two groups.

CONCLUSION:

Chamomile oil improved symptomatic and functional status of patients with severe carpal tunnel syndrome.

KEYWORDS:

Carpal tunnel syndrome; Chamomile oil; Herbal medicine; Matricaria chamomilla; Neuropathy; Traditional Persian Medicine

PMID:
26573447
DOI:
10.1016/j.ctcp.2015.08.001
[Indexed for MEDLINE]

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