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Lipids Health Dis. 2015 Nov 16;14:148. doi: 10.1186/s12944-015-0150-y.

Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population.

Author information

1
Department of Geriatrics, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, China. 250456230@qq.com.
2
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China. luojunyi3130@126.com.
3
Department of Geriatrics, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, China. zhangleitangtang@sina.com.
4
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China. yangyn5126@163.com.
5
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China. 247605749@qq.com.
6
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, Xinjiang, 830054, China. 604760840@qq.com.
7
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, Xinjiang, 830054, China. 825116852@qq.com.
8
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China. myt-xj@163.com.

Abstract

BACKGROUND:

Plasminogen activator inhibitor -2 (PAI-2) is an important molecular that plays a crucial role in vascular homeostasis and constitutes a critical response mechanism to cardiovascular injury, such as atherosclerosis, coronary artery disease (CAD).

METHODS:

The aim of the current study was to explore the association between the variants in PAI-2 gene and CAD and its prognoses. The three variants (rs8093048, rs9946657, rs9320032) of the PAI-2 gene were detected in 407 patients with CAD and 518 control subjects. All patients with CAD underwent one-year follow-up for major adverse cardiac events (MACE).

RESULTS:

The frequencies of the TT genotype and T allele of rs8093048 was significantly higher in CAD patients than that in control subjects (7.6% vs.3.5%, P = 0.003, 28.1 % vs.21.7%, P < 0.001, respectively). Multifactor logistic regression analysis showed that the TT genotype of rs8093048 was a risk factor for CAD (OR = 1.455, 95 % CI: 1.069-1.980, P = 0.017). In addition, the follow-up data showed that CAD patients with rs8093048 TT genotype had significantly higher rate of refractory angina and MACE than those with CC or CT genotype (P = 0.032, P = 0.009, respectively). Cox regression analysis showed that rs8093048 TT genotype was the risk factor for the MACE (Hazard ratio = 5.672, 95% CI = 1.992-16.152, P = 0.001).

CONCLUSION:

We firstly found that the variant of PAI-2 gene was associated with CAD and recurrent coronary event risk in Chinese Han population, in Xinjiang.

PMID:
26573152
PMCID:
PMC4647573
DOI:
10.1186/s12944-015-0150-y
[Indexed for MEDLINE]
Free PMC Article

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