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AIDS Res Hum Retroviruses. 2016 Apr;32(4):377-80. doi: 10.1089/AID.2015.0277. Epub 2016 Jan 7.

Short Communication: Limited HIV Pretreatment Drug Resistance Among Adults Attending Free Antiretroviral Therapy Clinic of Pune, India.

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1 HIV Drug Resistance Laboratory, National AIDS Research Institute , Pune, India .
2 Maharashtra University of Health Sciences , Nashik, India .
3 Department of Clinical Sciences, National AIDS Research Institute , Pune, India .
4 Department of Molecular Virology, National AIDS Research Institute , Pune, India .
5 Department of Microbiology, National AIDS Research Institute , Pune, India .
6 National AIDS Control Organization , New Delhi, India .


In India, the roll out of the free antiretroviral therapy (ART) program completed a decade of its initiation in 2014. The success of first-line ART is influenced by prevalence of HIV pretreatment drug resistance (PDR) in the population. In this cross-sectional study, we sought to determine the prevalence of PDR among adults attending the state-sponsored free ART clinic in Pune in western India. Fifty-two individuals eligible for ART as per national guidelines with median CD4 cell count of 253 cells/mm(3) (inter quartile range: 149-326) were recruited between January 2014 and April 2015. Population-based sequencing of partial pol gene sequences from plasma specimen revealed predominant HIV-1 subtype C infection (96.15%) and presence of single-drug resistance mutations against non-nucleoside reverse transcriptase inhibitor in two sequences. The study supports the need for periodic surveillance, when offering PDR testing at individual level is not feasible.

[Indexed for MEDLINE]

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