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Mol Neurobiol. 2016 Nov;53(9):6367-6376. doi: 10.1007/s12035-015-9526-2. Epub 2015 Nov 16.

Transgenerational Inheritance of Paternal Neurobehavioral Phenotypes: Stress, Addiction, Ageing and Metabolism.

Author information

1
School of Psychology, Nanjing Normal University, Nanjing, China. ytf0707@126.com.
2
Guangdong-Hong Kong-Macau Institute of CNS Regeneration (GHMICR), Guangdong Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, China. anglijnu@jnu.edu.cn.
3
Guangdong-Hong Kong-Macau Institute of CNS Regeneration (GHMICR), Guangdong Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, China.
4
Polytechnic Institute of Porto, School of Health Technologies, Porto, Portugal.
5
Unidad de Trastornos del Movimiento y Sueño (TMS), Hospital General Dr. Manuel Gea González/IFC-UNAM, Mexico City, Mexico.
6
Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro, Brazil.
7
Physical Activity Neuroscience, Physical Activity Sciences Postgraduate Program, Salgado de Oliveira University, Niterói, Brazil.
8
Institute of Cognitive Neuroscience and Department of Psychology, Zhejiang Sci-Tech University, Hangzhou, China. 13505818948@163.com.
9
Guangdong-Hong Kong-Macau Institute of CNS Regeneration (GHMICR), Guangdong Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, China. hrmaskf@hku.hk.
10
Department of Ophthalmology, LFS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. hrmaskf@hku.hk.
11
State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR, China. hrmaskf@hku.hk.

Abstract

Epigenetic modulation is found to get involved in multiple neurobehavioral processes. It is believed that different types of environmental stimuli could alter the epigenome of the whole brain or related neural circuits, subsequently contributing to the long-lasting neural plasticity of certain behavioral phenotypes. While the maternal influence on the health of offsprings has been long recognized, recent findings highlight an alternative way for neurobehavioral phenotypes to be passed on to the next generation, i.e., through the male germ line. In this review, we focus specifically on the transgenerational modulation induced by environmental stress, drugs of abuse, and other physical or mental changes (e.g., ageing, metabolism, fear) in fathers, and recapitulate the underlying mechanisms potentially mediating the alterations in epigenome or gene expression of offsprings. Together, these findings suggest that the inheritance of phenotypic traits through male germ-line epigenome may represent the unique manner of adaptation during evolution. Hence, more attention should be paid to the paternal health, given its equivalently important role in affecting neurobehaviors of descendants.

KEYWORDS:

Epigenetic modulation; Neurobehavior; Sperm; Transgenerational inheritance

PMID:
26572641
DOI:
10.1007/s12035-015-9526-2
[Indexed for MEDLINE]

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