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J Exp Psychol Gen. 2016 Mar;145(3):273-83. doi: 10.1037/xge0000121. Epub 2015 Nov 16.

Self-esteem modulates amygdala-ventrolateral prefrontal cortex connectivity in response to mortality threats.

Author information

1
Kokoro Research Center, Kyoto University.
2
School of Psychology and Public Health, La Trobe University.
3
Graduate School of Education, Kyoto University.

Abstract

Reminders of death often elicit defensive responses in individuals, especially among those with low self-esteem. Although empirical evidence indicates that self-esteem serves as a buffer against mortality threats, the precise neural mechanism underlying this effect remains unknown. We used functional magnetic resonance imaging (fMRI) to test the hypothesis that self-esteem modulates neural responses to death-related stimuli, especially functional connectivity within the limbic-frontal circuitry, thereby affecting subsequent defensive reactions. As predicted, individuals with high self-esteem subjected to a mortality threat exhibited increased amygdala-ventrolateral prefrontal cortex (VLPFC) connectivity during the processing of death-related stimuli compared with individuals who have low self-esteem. Further analysis revealed that stronger functional connectivity between the amygdala and the VLPFC predicted a subsequent decline in responding defensively to those who threaten one's beliefs. These results suggest that the amygdala-VLPFC interaction, which is modulated by self-esteem, can reduce the defensiveness caused by death-related stimuli, thereby providing a neural explanation for why individuals with high self-esteem exhibit less defensive reactions to mortality threats.

PMID:
26569130
DOI:
10.1037/xge0000121
[Indexed for MEDLINE]

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