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Sleep Med Clin. 2015 Dec;10(4):423-34. doi: 10.1016/j.jsmc.2015.08.002. Epub 2015 Sep 15.

Aging and Circadian Rhythms.

Author information

1
Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, BLI438, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: jduffy@hms.harvard.edu.
2
Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, BLI438, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.

Abstract

Aging is associated with numerous changes, including changes in sleep timing, duration, and quality. The circadian timing system interacts with a sleep-wake homeostatic system to regulate human sleep, including sleep timing and structure. This article reviews key features of the human circadian timing system, age-related changes in the circadian timing system, and how those changes may contribute to the observed alterations in sleep.

KEYWORDS:

Aging; Circadian; Human; Light; Melatonin; Sleep

PMID:
26568120
PMCID:
PMC4648699
DOI:
10.1016/j.jsmc.2015.08.002
[Indexed for MEDLINE]
Free PMC Article

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