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Heart Fail Clin. 2016 Jan;12(1):117-33. doi: 10.1016/j.hfc.2015.08.010.

Coronary Artery Disease and Diabetes Mellitus.

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Department of Cardiology, Rambam Medical Center, Technion, Israel Institute of Technology, P.O.B 9602, Haifa 31096, Israel. Electronic address:
Cardiovascular Division, Department of Medicine, Institute for Medical Science and Engineering, Massachusetts Institute of Technology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.


Diabetes mellitus (DM) is a major risk factor for cardiovascular disease. Near-normal glycemic control does not reduce cardiovascular events. For many patients with 1- or 2-vessel coronary artery disease, there is little benefit from any revascularization procedure over optimal medical therapy. For multivessel coronary disease, randomized trials demonstrated the superiority of coronary artery bypass grafting over multivessel percutaneous coronary intervention in patients with treated DM. However, selection of the optimal myocardial revascularization strategy requires a multidisciplinary team approach ('heart team'). This review summarizes the current evidence regarding the effectiveness of various medical therapies and revascularization strategies in patients with DM.


Blood glucose; Coronary disease; Diabetes mellitus; Hypoglycemic agents; Revascularization; Statins

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