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BMJ Case Rep. 2015 Nov 13;2015. pii: bcr2015211954. doi: 10.1136/bcr-2015-211954.

Opioid-induced constipation reversal in response to placebo in a patient with a history of IBS receiving methadone maintenance therapy.

Author information

1
Social & Epidemiological Research Department, Centre for Addiction and Mental Health, Toronto, Canada Addictions Program, Centre for Addiction and Mental Health, Toronto Canada.
2
Social & Epidemiological Research Department, Centre for Addiction and Mental Health, Toronto, Canada.

Abstract

Opioid-induced constipation (OIC) is one of the major side effects in patients receiving methadone maintenance treatment (MMT). Quite often, constipation becomes a factor significantly affecting therapeutic options and choices. Currently used approaches are symptomatic and in many cases ineffective. At the same time, it is well known that the gastrointestinal system is a subject for psychosomatic influences. In this case report, we describe an unexpected outcome of placebo administration in a patient suffering from OIC since her participation in MMT. The patient participated in a triple-blind randomised placebo-controlled trial of naloxone for treatment of OIC. As part of the study crossover design, the patient received 1 week of placebo followed by 1 week of naloxone, and had significant improvement in her bowel functioning when receiving placebo, then returned to baseline during the second week of the study.

PMID:
26567239
PMCID:
PMC4654218
DOI:
10.1136/bcr-2015-211954
[Indexed for MEDLINE]
Free PMC Article

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