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Adv Exp Med Biol. 2016;897:113-20. doi: 10.1007/5584_2015_5010.

Increase in Peripheral CD3-CD56brightCD16- Natural Killer Cells in Hashimoto's Thyroiditis Associated with HHV-6 Infection.

Author information

1
Department of Medical Sciences - Section of Microbiology and Medical Genetics, University of Ferrara, Via Luigi Borsari, 46, 44121, Ferrara, Italy.
2
Section of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
3
Department of Medical Sciences - Section of Microbiology and Medical Genetics, University of Ferrara, Via Luigi Borsari, 46, 44121, Ferrara, Italy. dario.diluca@unife.it.

Abstract

Hashimoto's thyroiditis (HT) is a very common autoimmune disease of the thyroid. In addition to genetic background, several viruses, including herpesviruses, have been suggested to play a role as possible environmental triggers of disease, but conclusive data are still lacking. Previous results showed that HT patients have an increased cellular immune response directed against the HHV-6 U94 protein and increased NK activity directed against HHV-6 infected thyrocytes.In this study, we characterized the antiviral antibody response and the NK cells activity and subtype in HHV-6 infected HT patients. The results showed that HT subjects have increased prevalence and titer of anti-U94 antibodies and a higher amount of CD3-CD56(bright)CD16(-)NK cell percentages compared to controls. Furthermore, the cell activation of CD3(-)CD56(bright) NK cells in HT patients significantly correlates with TPO and Tg Ab levels.The results suggest that HHV-6 might contribute to HT development, increasing NK cell secretion of inflammatory cytokines that could sustain the persistence of an inflammatory status in HT patients.

KEYWORDS:

HHV-6; Hashimoto’s thyroiditis; NK cells

PMID:
26566646
DOI:
10.1007/5584_2015_5010
[Indexed for MEDLINE]

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