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Open Forum Infect Dis. 2015 Sep 19;2(4):ofv140. doi: 10.1093/ofid/ofv140. eCollection 2015 Dec.

Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis.

Author information

1
University of Washington School of Medicine.
2
Department of Medicine.
3
Division of Allergy and Infectious Diseases, Department of Medicine , University of Washington ; Global Oncology, Vaccine and Infectious Disease Division , Fred Hutchinson Cancer Research Center , Seattle, Washington.
4
Division of Allergy and Infectious Diseases, Department of Medicine , University of Washington.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) in immunocompromised hosts is a fulminant syndrome of immune activation with high rates of mortality that may be triggered by infections or immunodeficiency. Rapid diagnosis and treatment of the underlying disorder is necessary to prevent progression to multiorgan failure and death. We report a case of HLH in a patient with human immunodeficiency virus, disseminated histoplasmosis, Mycobacterium avium complex, and Escherichia coli bacteremia. We discuss management of acutely ill patients with HLH and treatment of the underlying infection versus initiation of HLH-specific chemotherapy.

KEYWORDS:

HIV; HLH; histoplasmosis

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