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J Gynecol Obstet Biol Reprod (Paris). 2016 Sep;45(7):738-44. doi: 10.1016/j.jgyn.2015.09.002. Epub 2015 Nov 10.

[Preliminary results from the French study on prenatal repair for fetal myelomeningoceles (the PRIUM study)].

[Article in French]

Author information

1
Service de médecine fœtale, centre pluridisciplinaire de l'Est Parisien, hôpital Armand-Trousseau, AP-HP, Paris 6, 26, avenue Arnold-Netter, 75012 Paris, France.
2
Service de neurochirurgie pédiatrique, hôpital Necker-Enfants-Malades, AP-HP, Paris 5, 49, rue de Sèvres, 75015 Paris, France.
3
Département d'anesthésie, hôpital Armand-Trousseau, AP-HP, Paris 6, 26, avenue Arnold-Netter, 75012 Paris, France.
4
Service de radiopédiatrie, hôpital Armand-Trousseau, AP-HP, Paris 6, 26, avenue Arnold-Netter, 75012 Paris, France.
5
Unité pédiatrique de médecine physique et de réadaptation, hôpital Armand-Trousseau, AP-HP, Paris 6, 26, avenue Arnold-Netter, 75012 Paris, France.
6
Service de neuropédiatrie, hôpital Armand-Trousseau, AP-HP, Paris 6, 26, avenue Arnold-Netter, 75012 Paris, France.
7
Service de médecine fœtale, centre pluridisciplinaire de l'Est Parisien, hôpital Armand-Trousseau, AP-HP, Paris 6, 26, avenue Arnold-Netter, 75012 Paris, France. Electronic address: jean-marie.jouannic@trs.aphp.fr.

Abstract

OBJECTIVES:

To present the preliminary results of the PRIUM study, a French pilot study of prenatal repair for myelomeningoceles (MMC).

MATERIAL AND METHODS:

The fetal surgery for MMC is offered in cases of patients that did not opt for termination of pregnancy.

RESULTS:

Thirty-six patients were referred in an 18-month period. Eight patients were not eligible for prenatal repair. Another type of dysraphism was made in 6 cases (one spina-lipoma, 5 cases of limited dorsal myeloschisis). Twenty-two patients were eligible to fetal surgery. A prenatal repair was performed in three cases (14%). Four patients opted for a conventional postnatal treatment. Fifteen patients opted for termination of the pregnancy.

CONCLUSION:

The establishment of a prenatal repair of MMC protocol in France was justified. The experience of the first 18months of this study however suggests that only a limited number of couples will choose this procedure after specialized counseling in a reference center.

KEYWORDS:

Chirurgie fœtale; Diagnostic prénatal; Fetal surgery; Myelomeningocele; Myéloméningocèle; Prenatal diagnosis

PMID:
26566108
DOI:
10.1016/j.jgyn.2015.09.002
[Indexed for MEDLINE]
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