Format

Send to

Choose Destination
Autophagy. 2015;11(12):2375-6. doi: 10.1080/15548627.2015.1106668.

MTOR, PIK3C3, and autophagy: Signaling the beginning from the end.

Author information

1
a MRC Protein Phosphorylation and Ubiquitylation Unit; College of Life Sciences; University of Dundee ; Dundee , UK.

Abstract

A key point in starvation-induced autophagy occurs at the end of the process, where lysosomes are regenerated from autolysosomes through a pathway termed autophagic lysosome reformation (ALR). ALR occurs when autolysosomal MTOR becomes reactivated by amino acids derived from the autophagic delivery of protein cargo. This activation not only turns off autophagosome formation but also leads to reformation of lysosomes, ready for the next round of autophagy, through a series of events involving autolysosomal tubulation. We have now found that MTOR regulates multiple steps of ALR including direct activation of the PIK3C3-UVRAG lipid kinase complex to enable autolysosomal tubules to break away and regenerate lysosomes.

KEYWORDS:

MTOR; UVRAG; VPS34; autophagic lysosome reformation; lysosome; phosphatidylinositol 3-phosphate; tubulation

PMID:
26565689
PMCID:
PMC4835211
DOI:
10.1080/15548627.2015.1106668
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center