Send to

Choose Destination
J Pak Med Assoc. 2015 Nov;65(11):1197-201.

Is chlorhexidine-gluconate superior than Povidone-Iodine in preventing surgical site infections? A multicenter study.

Author information

MRC Research Centre, JPMC, Karachi.
Pakistan Institute of Medical Sciences, Islamabad.
Jinnah Postgraduate Medical Centre, Karachi.
PMRC Research Centre, JPMC, Karachi.



To compare the efficacy of povidone-iodine and chlorhexidine gluconate scrubs in preventing surgical site infections.


The randomised controlled clinical trial was conducted from May 2012 to April 2013 in two public-sector hospitals of Pakistan; one each in Karachi and Islamabad. Patients undergoing clean or clean contaminated surgeries were included and were randomly assigned to one of the two groups: group I comprised patients whose skin was preoperatively disinfected using 10% povidone-iodine, and in group II by 2% chlorhexidine gluconate in 70% alcohol. A predesigned proforma was filled for all patients to record demographic data, diagnosis, surgical procedure and antibiotic used. Patients in both groups were followed up for one month postoperatively to monitor any signs of surgical site infections. SPSS 16 was used for statistical analysis.


Of the 388 patients from the two hospitals, 220(57%) were in group I and 168(43%) were in group II. Surgical site infection was observed in 22(10%) cases in group I and 12(7.1%) in group II (p=0.324). Pseudomonas aeruginosa (23.5%) was the predominant pathogen associated with surgical site infections followed by Staphylococcus aureus (17.6%).


Chlorhexidine gluconate was associated with lower infection rates compared to povidone-iodine; but it was not statistically significant.


Povidone-iodine, Chlorhexidine gluconate scrubs, Surgical site infections.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Pakistan Medical Association
Loading ...
Support Center