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Org Biomol Chem. 2016 Jan 14;14(2):440-446. doi: 10.1039/c5ob02080h.

Targeting anti-apoptotic Bcl2 proteins with scyllatoxin-based BH3 domain mimetics.

Author information

1
Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA. holub@ohio.edu.

Abstract

BH3 domain mimetics based on the small protein scyllatoxin (ScTx) were designed to target the anti-apoptotic protein Bcl2 in vitro. Intrinsically disordered ScTx variants were found to bind Bcl2 with nanomolar affinity, indicating that an induced fit binding mechanism is required for favorable BH3 : Bcl2 interaction.

PMID:
26563651
DOI:
10.1039/c5ob02080h
[Indexed for MEDLINE]

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