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J Pediatr Surg. 2016 Jan;51(1):44-8. doi: 10.1016/j.jpedsurg.2015.10.009. Epub 2015 Oct 22.

Risk-stratification of severity for infants with CDH: Prenatal versus postnatal predictors of outcome.

Author information

1
Texas Children's Fetal Center, Houston, TX; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX.
2
Texas Children's Fetal Center, Houston, TX; Department of Pediatrics, Baylor College of Medicine, Houston, TX.
3
Texas Children's Fetal Center, Houston, TX; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX; Department of Pediatrics, Baylor College of Medicine, Houston, TX; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX.
4
Texas Children's Fetal Center, Houston, TX; Department of Radiology, Baylor College of Medicine, Houston, TX.
5
Texas Children's Fetal Center, Houston, TX; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX.
6
Texas Children's Fetal Center, Houston, TX; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX; Department of Pediatrics, Baylor College of Medicine, Houston, TX; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX. Electronic address: dlcass@texaschildrens.org.

Abstract

PURPOSE:

The purpose of this study was to compare the predication accuracy of a newly described postnatally-based clinical prediction model to fetal imaging-based predictors of mortality for infants with CDH.

METHODS:

We performed a retrospective review of all CDH patients treated at a comprehensive fetal care center from January 2004 to January 2014. Prenatal data reviewed included lung-to-head ratio (LHR), observed/expected-total fetal lung volume (O/E-TFLV), and percent liver herniation (%LH). Based on the postnatal prediction model, neonates were categorized as low, intermediate, and high risk of death. The primary outcome was 6-month mortality.

RESULTS:

Of 176 CDH patients, 58 had a major cardiac anomaly, and 28 had a genetic anomaly. Patients with O/E-TFLV <35% and %LH >20% were at increased risk for mortality (44% and 36%, respectively). There was a significant difference in mortality between low, intermediate, and high-risk groups (4% vs. 22% vs. 51%; p<0.001). On multivariate regression, the O/E-TFLV and postnatal-based mortality risk score were the two independent predictors of 6-month mortality.

CONCLUSION:

The CDH Study Group postnatal predictive model provides good discrimination among three risk groups in our patient cohort. The prenatal MRI-based O/E-TFLV is the strongest prenatal predictor of 6-month mortality in infants with CDH and will help guide prenatal counseling and discussions regarding fetal intervention and perinatal management.

KEYWORDS:

CDH; Fetal lung volumes; Prenatal predictors; Risk stratification

PMID:
26563530
DOI:
10.1016/j.jpedsurg.2015.10.009
[Indexed for MEDLINE]

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