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Eur J Pharmacol. 1989 Apr 25;163(2-3):365-7.

Inotropic effects of endothelin in ferret ventricular myocardium.

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Department of Cardiology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.


The characteristics of the inotropic response to endothelin were studied in isolated ferret papillary muscle preparations. Endothelin (0.1-10 nM) induced concentration-dependent positive inotropic effects. At 10 nM, isometric tension increased by 17%, maximum rate of tension development by 18%, maximum velocity of unloaded shortening by 23% and peak isotonic shortening by 11%. Time to peak isometric tension and half isometric relaxation time were unaltered by endothelin. This pattern of change is similar to that of elevating extracellular calcium concentration.

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