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Clin Nucl Med. 2016 Jan;41(1):53-4. doi: 10.1097/RLU.0000000000001023.

Metastatic Insulinoma Pancreatic Neuroendocrine Tumor Treated With 177Lu-DOTATATE Induction and Maintenance Peptide Receptor Radionuclide Therapy: A Suggested Protocol.

Author information

1
From the Department of Diagnostic Imaging, Cross Cancer Institute, Edmonton, Alberta, Canada.

Abstract

A 70-year-old woman presented with frequent episodes of hypoglycemia. Imaging revealed a 6-cm pancreatic mass with several liver lesions. The pancreatic mass was resected and confirmed to be a well-differentiated insulinoma. Surgery improved but did not resolve her hypoglycemic episodes, and she was referred for peptide receptor radionuclide therapy with 177Lu-DOTATATE to treat her residual disease. A modified protocol with a continuous IV dextrose infusion was used, and the treatments were well tolerated. After 4 induction and 2 maintenance treatments, her hypoglycemic symptoms resolved completely and her disease stabilized. She has been progression free for 24 months.

PMID:
26562579
DOI:
10.1097/RLU.0000000000001023
[Indexed for MEDLINE]

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