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Head Neck. 2016 Apr;38 Suppl 1:E1481-7. doi: 10.1002/hed.24263. Epub 2015 Nov 11.

Prospective randomized controlled trial to compare 3-dimensional conformal radiotherapy to intensity-modulated radiotherapy in head and neck squamous cell carcinoma: Long-term results.

Author information

1
Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
2
Department of Radiation Oncology, Kasturba Medical College, Manipal, Karnataka, India.
3
Department of Radiation Oncology, Apollo Speciality Cancer Hospital, Chennai, Tamil Nadu, India.
4
Department of Radiation Oncology, Advanced Center for Treatment, Research, and Education in Cancer (ACTREC), Navi Mumbai, Maharashtra, India.

Abstract

BACKGROUND:

Grade ≥2 acute xerostomia between 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) was evaluated in patients with head and neck squamous cell carcinomas (HNSCCs) treated radically.

METHODS:

Between 2005 and 2007, 59 patients with HNSCC (T1-3, N0-2b) were randomized to IMRT or 3D-RT. On RT, weekly xerostomia, dysphagia, dermatitis, and mucositis were graded by Radiation Therapy Oncology Group (RTOG) acute toxicity criteria. Patients underwent examination under anesthesia, positron emission tomography (PET)-CT, and toxicity assessments per protocol (NCT00652613) thereafter.

RESULTS:

Incidence of grade ≥2 xerostomia at 8 weeks posttreatment was significantly lower with IMRT compared with 3D conformal RT (24% vs 53%; p = .024). At subsequent follow-up, significantly fewer patients receiving IMRT had grade ≥2 xerostomia. Long-term weight loss was higher in patients in the 3D conformal RT arm compared to IMRT (50% vs 21%; p = .038). Disease-related outcomes between arms (median follow-up, 70 months) were similar.

CONCLUSION:

IMRT significantly reduces incidence of acute and late grade ≥2 xerostomia in patients with HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1481-E1487, 2016.

KEYWORDS:

conformal radiotherapy; head and neck cancer; intensity-modulated radiotherapy (IMRT); squamous cell carcinoma

PMID:
26561342
DOI:
10.1002/hed.24263
[Indexed for MEDLINE]

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