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N Engl J Med. 2015 Nov 12;373(20):1895-8. doi: 10.1056/NEJMp1508811.

The Path to Cancer --Three Strikes and You're Out.

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1
From the Ludwig Center and Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore.

Abstract

Focusing on driver-gene mutations and the pathways they control has rendered complex cancer-genome landscapes intelligible. In solid tumors of adults, alterations in as few as three driver genes appear to suffice for a cell to evolve into an advanced cancer.

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PMID:
26559569
DOI:
10.1056/NEJMp1508811
[Indexed for MEDLINE]

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