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Cell Motil Cytoskeleton. 1989;12(4):225-47.

Functional diversity among spectrin isoforms.

Author information

1
Department of Biology, Yale University, New Haven, CT 06511-8112.

Abstract

The purpose of this review on spectrin is to examine the functional properties of this ubiquitous family of membrane skeletal proteins. Major topics include spectrin-membrane linkages, spectrin-filament linkages, the subcellular localization of spectrins in various cell types and a discussion of major functional differences between erythroid and nonerythroid spectrins. This includes a summary of studies from our own laboratories on the functional and structural comparison of avian spectrin isoforms which are comprised of a common alpha subunit and a tissue-specific beta subunit. Consequently, the observed differences among these spectrins can be assigned to differences in the properties of the beta subunits.

PMID:
2655937
DOI:
10.1002/cm.970120405
[Indexed for MEDLINE]

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