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Crit Rev Eukaryot Gene Expr. 2015;25(4):315-21.

Implications of Mycobacterium Major Facilitator Superfamily for Novel Measures against Tuberculosis.

Author information

1
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Three Gorges Eco-environment and Bioresources, Key Laboratory Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, School of Life Sciences, Southwest Univ.
2
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
3
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing, China.
4
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing, China.

Abstract

Major facilitator superfamily (MFS) is an important secondary membrane transport protein superfamily conserved from prokaryotes to eukaryotes. The MFS proteins are widespread among bacteria and are responsible for the transfer of substrates. Pathogenic Mycobacterium MFS transporters, their distribution, function, phylogeny, and predicted crystal structures were studied to better understand the function of MFS and to discover specific inhibitors of MFS for better tuberculosis control.

PMID:
26559092
[Indexed for MEDLINE]

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