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Dement Geriatr Cogn Dis Extra. 2015 Sep 30;5(3):375-85. doi: 10.1159/000439043. eCollection 2015 Sep-Dec.

Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life.

Author information

1
Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands.
2
Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands ; Department of Epidemiology and Biostatistics, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands.
3
Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands.

Abstract

BACKGROUND:

After hypertensive disorders of pregnancy, more subjective cognitive complaints and white matter lesions are reported compared to women after normal pregnancies. Both have a causal relationship with Alzheimer's disease (AD).

AIM:

To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD.

METHODS:

A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed.

RESULTS:

The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD.

CONCLUSION:

A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life.

KEYWORDS:

Alzheimer's disease; Early-onset dementia; Magnetic resonance imaging; Preeclampsia; Pregnancy-induced hypertension

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