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Case Rep Ophthalmol. 2015 Oct 7;6(3):345-50. doi: 10.1159/000440762. eCollection 2015 Sep-Dec.

Primary Vitreoretinal Lymphoma Masquerading as Refractory Retinitis.

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The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, and The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.



To report a case of a patient with primary vitreoretinal lymphoma masquerading as retinitis.


Retrospective review of the patient's clinical, histopathological and imaging records.


Cytopathology was negative for malignancy, and preliminary polymerase chain reaction results supported the diagnosis of varicella zoster virus retinitis. Therefore, the patient was treated with antiviral therapy. However, under this treatment, the retinitis progressed. As a result, primary vitreoretinal lymphoma was suspected, and empirical treatment with intravitreal methotrexate injections was started. Under this treatment, the ocular features improved. Five months after initial ocular presentation and ocular resolution, the patient presented with central nervous system lymphoma.


This case should raise the awareness of the variable clinical presentations, the challenging diagnosis and treatment of primary vitreoretinal lymphoma. All cases should be continuously systemically evaluated.


Diagnostic vitrectomy; Intravitreal methotrexate; Posterior uveitis; Primary central nervous system lymphoma; Primary vitreoretinal lymphoma

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