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Cancer Cell. 2015 Nov 9;28(5):548-549. doi: 10.1016/j.ccell.2015.10.011.

Sugar Makes Fat by Talking to SCAP.

Author information

1
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: peter.espenshade@jhmi.edu.

Abstract

Elevated blood glucose promotes lipogenesis via activating SREBP transcription factors. Tumors exhibit increased glucose uptake and lipogenesis, but the mechanisms controlling this are poorly understood. In this issue of Cancer Cell, Cheng and colleagues find that glucose activates SREBP by stabilizing SCAP, a central regulator of the SREBP pathway.

PMID:
26555169
PMCID:
PMC4772404
DOI:
10.1016/j.ccell.2015.10.011
[Indexed for MEDLINE]
Free PMC Article

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