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Infect Dis (Lond). 2016 Apr;48(4):270-273. doi: 10.3109/23744235.2015.1109134. Epub 2015 Nov 10.

Human papillomavirus and its clinical relevance in oesophageal squamous cell carcinoma in a Kurdish population in the west of Iran.

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a Cellular and Molecular Research Center, Kurdistan University of Medical Sciences , Sanandaj , Iran.
b Departments of Marine Biology , Faculty of Marine Sciences, Chabahar Maritime University , Chabahar , Iran.
c Department of Pathology , Kermanshah University of Medical Sciences , Kermanshah , Iran.
d Department of Oncology-Pathology , Karolinska Institute, Karolinska University Hospital , Stockholm , Sweden.
e Department of Community Medicine & Kurdistan Research Center for Social Determinants of Health , Kurdistan University of Medical Sciences , Sanandej , Iran.
f Departments of Statistic and Basic Science , Chabahar Maritime University , Chabahar , Iran.
g Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences , Rafsanjan , Iran.


Background The aetiological role of Human Papillomavirus (HPV) in oesophageal squamous cell carcinoma (ESCC) was evaluated by assessment of the presence and status of HPV DNA in a Kurdish population in the west of Iran. Methods One hundred and three paraffin-embedded ESCC tissue samples, diagnosed between 2007-2013, were included in the study. DNA was extracted and then HPV presence and genotypes were determined by PCR and INNO-LiPA genotyping, respectively. Results HPV DNA was detected in 11/103 (10.7%) of ESCCs. HPV-18 and HPV-16 genotypes were determined in five and six samples, respectively. Co-infection of HPV-6 was only found with HPV-18 in two cases. There were no statistically significant distinctions between HPV-positive and HPV-negative cases with regard to clinical and pathologic findings. Conclusion The present study indicates that, among a group of Kurdish people in two provinces in the west of Iran, as a low-risk ESCC area, HPV could be one of the risk factors, although in a small proportion of the patients.


ESCC; HPV; Kurdish population; oesophageal squamous cell carcinoma

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