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Obesity (Silver Spring). 2016 Jan;24(1):231-7. doi: 10.1002/oby.21258. Epub 2015 Nov 11.

Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study.

Author information

1
Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, Rhode Island, USA.
2
Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA.
3
Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
4
Child and Family Research Institute, BC Children's and Women's Hospital, Vancouver, British Columbia, Canada.
5
Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
6
Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Abstract

OBJECTIVE:

To examine relationships between prenatal perfluoroalkyl substance (PFAS) exposure and adiposity in children born to women who lived downstream from a fluoropolymer manufacturing plant.

METHODS:

Data are from a prospective cohort in Cincinnati, Ohio (HOME Study). Perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), and perfluorohexane sulfonic (PFHxS) acids were measured in prenatal serum samples. Differences were measured in body mass index z-scores (BMI), waist circumference, and body fat at 8 years of age (n = 204) and BMI between 2-8 years of age (n = 285) according to PFAS concentrations.

RESULTS:

Children born to women in the top two PFOA terciles had greater adiposity at 8 years than children in the 1st tercile. For example, waist circumference (cm) was higher among children in the 2nd (4.3; 95% CI: 1.7, 6.9) and 3rd tercile (2.2; 95% CI: -0.5, 4.9) compared to children in the 1st tercile. Children in the top two PFOA terciles also had greater BMI gains from 2 to 8 years compared to children in the 1st tercile (P < 0.05). PFOS, PFNA, and PFHxS were not associated with adiposity.

CONCLUSIONS:

In this cohort, higher prenatal serum PFOA concentrations were associated with greater adiposity at 8 years and a more rapid increase in BMI between 2-8 years.

PMID:
26554535
PMCID:
PMC4688224
DOI:
10.1002/oby.21258
[Indexed for MEDLINE]
Free PMC Article

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