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Mult Scler. 2016 Sep;22(10):1371-5. doi: 10.1177/1352458515615954. Epub 2015 Nov 9.

Seronegative neuromyelitis optica spectrum disorder patients diagnosed using new diagnostic criteria.

Author information

1
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan auzawa@chiba-u.jp.
2
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Abstract

BACKGROUND:

Recently, new diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD) were published.

OBJECTIVE:

Our primary aim was to evaluate the usefulness of the new diagnostic criteria in anti-aquaporin 4 (AQP4) antibody-negative cases.

METHODS:

Consecutive 471 patients whose anti-AQP4 antibody was measured at Chiba University were reviewed.

RESULTS:

Four anti-AQP4 antibody negative-patients, who fulfilled the new diagnostic criteria for NMOSD but not 2006 diagnostic criteria for neuromyelitis optica (NMO), were identified. They showed high cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels, an absence of oligoclonal bands and/or cloud-like enhancement on magnetic resonance imaging, which are compatible findings for NMO.

CONCLUSION:

The new diagnostic criteria are clinically useful in seronegative NMOSD.

KEYWORDS:

Diagnostic criteria; glial fibrillary acidic protein; interleukin-6; neuromyelitis optica; seronegative

PMID:
26552730
DOI:
10.1177/1352458515615954
[Indexed for MEDLINE]

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