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Mult Scler. 2016 Sep;22(10):1367-70. doi: 10.1177/1352458515615226. Epub 2015 Nov 9.

Optimal detection of infratentorial lesions with a combined dual-echo MRI sequence: "PT2".

Author information

1
Department of Neurology, Dr. Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina migaitan@fleni.org.ar.
2
Department of Radiology, Dr. Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina.
3
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
4
Department of Neurology, Dr. Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina.

Abstract

BACKGROUND:

The infratentorial compartment is cardinal for multiple sclerosis (MS) diagnosis. T2-weighted (T2) and proton density-weighted (PD) magnetic resonance imaging (MRI) can visualize infratentorial lesions, but only suboptimally.

OBJECTIVE:

To combine PD and T2 for better lesion assessment.

METHODS:

T2 and PD from 35 cases were averaged to form "PT2" images. Two raters counted infratentorial lesions and qualitatively assessed their conspicuity.

RESULTS:

PT2 showed 244 infratentorial lesions, of which 94% and 74% were seen in PD and T2. PT2 received higher grades for image quality and lesion conspicuity (p < 0.001 for all comparisons).

CONCLUSION:

PT2 could improve our ability to diagnose and monitor MS.

KEYWORDS:

MRI; Multiple sclerosis; T2 lesions; infratentorial brain

PMID:
26552729
PMCID:
PMC5267321
DOI:
10.1177/1352458515615226
[Indexed for MEDLINE]
Free PMC Article

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