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Int J Clin Exp Med. 2015 Aug 15;8(8):13874-8. eCollection 2015.

A meta-analysis of XPD/ERCC2 Lys751Gln polymorphism and melanoma susceptibility.

Author information

1
Department of Traditional Chinese Medicine, People's Hospital of Pudong New District Shanghai, China.
2
Department of Pathology, Fudan University Shanghai Cancer Center Shanghai, China ; Department of Oncology, Shanghai Medical College, Fudan University Shanghai, China.
3
Department of Traditional Chinese Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China.
4
Department of Integrated Traditional Chinese and Western Medicine, Shanghai Dermatology Hospital Shanghai, China.
5
Department of Integrated Oncology, Fudan University Shanghai Cancer Center Shanghai, China ; Department of Oncology, Shanghai Medical College, Fudan University Shanghai, China.

Abstract

We performed a comprehensive meta-analysis to determine the association between XPD/ERCC2 Lys751Gln polymorphism and melanoma susceptibility. Based on comprehensive searches of the MEDLINE, EMBASE and ISI Web of knowledge, China National Knowledge Infrastructure (CNKI) and Wanfang Database, we identified eligible studies about the association between XPD/ERCC2 Lys751Gln polymorphism and melanoma risk. A total of 5,961 cases and 8,669 controls in studies were included in this meta-analysis. All studies were conducted in Caucasian populations. Allele model (Lys vs. Gln: P = 0.53; OR = 0.98, 95% CI = 0.91-1.05), and homozygous model (Lys/ Lys vs. Gln/Gln: P = 0.32; OR = 0.93, 95% CI = 0.81 to 1.07) did not show increased risk of developing melanoma. Similarly, dominant model (Lys/ Lys+Lys/Gln vs. Gln/Gln: P = 0.18; OR = 0.93, 95% CI = 0.83 to 1.03) and recessive model (Lys/ Lys vs. Lys/Gln+Gln/Gln: P = 0.73; OR = 0.98, 95% CI = 0.88 to 1.09) failed to show increased risk of developing melanoma. Our pooled data suggest that there was no evidence for a major role of XPD/ERCC2 Lys751Gln polymorphism in the pathogenesis of melanoma among Caucasian populations.

KEYWORDS:

ERCC2; XPD; melanoma; meta-analysis

PMID:
26550341
PMCID:
PMC4613026

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