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Int J Clin Exp Med. 2015 Aug 15;8(8):12529-38. eCollection 2015.

Association of homocysteine with type 1 diabetes mellitus: a meta-analysis.

Author information

1
Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
2
Department of Rheumatology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.

Abstract

PURPOSE:

To figure out the association between plasma Hcy status and type 1 diabetes mellitus (T1DM).

METHODS:

We searched the PubMed Web of Science, and The Cochrane Library to identify eligible studies. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of selected studies. All analyses were performed using the STATA, version 12 software.

RESULTS:

15 studies were included in this investigation. Our meta-analysis indicated that plasma Hcy concentrations in T1DM patients without any complications were normal compared with healthy people [13 studies, SMD: -0.08, 95% confidence interval (CI): -0.44 to 0.28, P=0.67]. However, a significant elevation of plasma Hcy concentrations was observed in T1DM patients with only diabetic retinopathy (DR) (5 studies, SMD: 0.34, 95% CI: 0.13 to 0.55, P=0.002), only diabetic nephropathy (DN) (4 studies, SMD: 0.76, 95% CI: 0.18 to 1.33, P=0.01) and both the two complications (3 studies, SMD: 1.05, 95% CI: 0.03 to 2.07, P=0.043) compared with T1DM patients without any complications.

CONCLUSIONS:

Homocysteine levels elevate in T1DM patients with DR and DN, but don't elevate in T1DM without any complications.

KEYWORDS:

Homocysteine; diabetic nephropathy; diabetic retinopathy; meta-analysis; type 1 diabetes mellitus

PMID:
26550163
PMCID:
PMC4612848

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