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Int J Clin Exp Med. 2015 Aug 15;8(8):12041-55. eCollection 2015.

Evaluation of activity of an estrogen-derivative as cardioprotector drug using an ischemia-reperfusion injury model.

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Laboratory of Pharmaco-Chemistry at The Faculty of Chemical Biological Sciences From The University Autonomous of Campeche Av. Agustín Melgar s/n, Col Buenavista C.P. 24039 Campeche Cam., México.
Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas D.F. C.P. 11340, México.
Facultad de Nutrición, Universidad Veracruzana, Médicos y Odontólogos s/n Xalapa Veracruz 91010, México.


Myocardial ischemia/reperfusion injury is a serious problem involved in cardiovascular diseases. There data which indicate that some steroids induce cardioprotective effects on myocardial ischemia-reperfusion injury; however their activity and the molecular mechanism involved on myocardial ischemia-reperfusion injury are very confusing. Therefore, in this study some estrogen derivatives (compound 3 to 7) were synthesized with the objective of evaluating its activity on myocardial ischemia/reperfusion injury using an isolated heart model. Additionally, molecular mechanism involved in the activity exerted by the compounds 3 to 7 on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds; prazosin, metoprolol, indomethacin and nifedipine. The results showed that 7 reduce infarct size compared with the estrone and other estrogen derivatives (compounds 3, 4, 5, and 6). Other results showed that 7 significantly increase the perfusion pressure and coronary resistance in isolated heart in comparison with estrone, 3, 4, 5, and 6. Finally, other data indicate that 7 increased the left ventricular pressure in a dose-dependent manner; however, this phenomenon was significantly inhibited by nifedipine. In conclusion, all these data suggest that 7 exert a cardioprotective effect through calcium channels activation and consequently induce changes in the left ventricular pressure levels. This phenomenon results in decrease of myocardial necrosis after ischemia and reperfusion.


Estrogen; ischemia/reperfusion injury left ventricular pressure; nifedipine


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