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Int J Clin Exp Med. 2015 Aug 15;8(8):11958-84. eCollection 2015.

The role of gene variants of the inflammatory markers CRP and TNF-α in cardiovascular heart disease: systematic review and meta-analysis.

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Universidad Juárez Autónoma de Tabasco, División Multidisciplinaria de Jalpa de Méndez Cunduacán, Tabasco, México.
Universidad Juárez Autónoma de Tabasco, División Multidisciplinaria de Comalcalco Comalcalco, Tabasco, México.
Universidad Juárez Autónoma de Tabasco, División Académica de Ciencias de la Salud Villahermosa, Tabasco, México.
Hospital de Alta Especialidad "Juan Graham Casasús" Villahermosa, Tabasco, México.
Hospital General de Yajalón. Secretaría de Salud Yajalón, Chiapas, México.
Instituto Mexicano del Seguro Social Villahermosa, Tabasco.


It is widely acknowledged that cardiovascular heart disease (CHD) has a genetic influence. Several studies have investigated the role of inflammatory markers like C-reactive protein (CRP) and tumor necrosis factor α (TNF-α) in the causation of cardiovascular diseases. Although there have been several positive studies associating CRP and TNF-α genes with CHD, the evidence is not entirely consistent. Therefore, we performed a meta-analysis to gain a better understanding into this issue. The meta-analysis was conducted with 22 articles of genetic association studies of CRP (G1059C rs1800947, C1444T rs1130864, C717T rs2794521 and G3872A rs1205) and TNF-α (C857T rs1799724, C863A rs1800630 and T1031C rs1799964) genes. To analyze the association of these variants with CHD we used the following models: allelic, additive, dominant and recessive. In addition, we performed a sub-group analysis by Caucasian population using the same four models. CRP and TNF-α gene polymorphisms showed a positive significant association with CHD. This study provides evidence that rs2794521 of the CRP gene and rs1799724, rs1800630 and rs1799964 of the TNF-α gene polymorphisms may be risk factors to manifest CHD. The analysis of rs1800947 and rs1205 of the CRP gene yielded a protective effect in the pathogenesis of this disease. Only the analysis of the rs1130864 polymorphism showed a lack of association with CHD. To have conclusive outcomes it is necessary to integrate more studies to confirm our findings.


C-reactive protein; Cardiovascular disease; TNF-α; meta-analysis and systematic review; polymorphisms


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