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Int J Clin Exp Med. 2015 Aug 15;8(8):11958-84. eCollection 2015.

The role of gene variants of the inflammatory markers CRP and TNF-α in cardiovascular heart disease: systematic review and meta-analysis.

Author information

1
Universidad Juárez Autónoma de Tabasco, División Multidisciplinaria de Jalpa de Méndez Cunduacán, Tabasco, México.
2
Universidad Juárez Autónoma de Tabasco, División Multidisciplinaria de Comalcalco Comalcalco, Tabasco, México.
3
Universidad Juárez Autónoma de Tabasco, División Académica de Ciencias de la Salud Villahermosa, Tabasco, México.
4
Hospital de Alta Especialidad "Juan Graham Casasús" Villahermosa, Tabasco, México.
5
Hospital General de Yajalón. Secretaría de Salud Yajalón, Chiapas, México.
6
Instituto Mexicano del Seguro Social Villahermosa, Tabasco.

Abstract

It is widely acknowledged that cardiovascular heart disease (CHD) has a genetic influence. Several studies have investigated the role of inflammatory markers like C-reactive protein (CRP) and tumor necrosis factor α (TNF-α) in the causation of cardiovascular diseases. Although there have been several positive studies associating CRP and TNF-α genes with CHD, the evidence is not entirely consistent. Therefore, we performed a meta-analysis to gain a better understanding into this issue. The meta-analysis was conducted with 22 articles of genetic association studies of CRP (G1059C rs1800947, C1444T rs1130864, C717T rs2794521 and G3872A rs1205) and TNF-α (C857T rs1799724, C863A rs1800630 and T1031C rs1799964) genes. To analyze the association of these variants with CHD we used the following models: allelic, additive, dominant and recessive. In addition, we performed a sub-group analysis by Caucasian population using the same four models. CRP and TNF-α gene polymorphisms showed a positive significant association with CHD. This study provides evidence that rs2794521 of the CRP gene and rs1799724, rs1800630 and rs1799964 of the TNF-α gene polymorphisms may be risk factors to manifest CHD. The analysis of rs1800947 and rs1205 of the CRP gene yielded a protective effect in the pathogenesis of this disease. Only the analysis of the rs1130864 polymorphism showed a lack of association with CHD. To have conclusive outcomes it is necessary to integrate more studies to confirm our findings.

KEYWORDS:

C-reactive protein; Cardiovascular disease; TNF-α; meta-analysis and systematic review; polymorphisms

PMID:
26550110
PMCID:
PMC4612795

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