Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2015 Dec 15;25(24):5712-5. doi: 10.1016/j.bmcl.2015.10.092. Epub 2015 Nov 2.

A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment.

Author information

1
School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
2
College of Pharmacy, CHA University, Pocheon 487-010, Republic of Korea.
3
Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong 369-873, Republic of Korea.
4
College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea.
5
College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea. Electronic address: kkang@gachon.ac.kr.
6
School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea. Electronic address: khkim83@skku.edu.

Abstract

A new cerebroside, cerebroside E (1) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae). The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions. Compound 1 was evaluated for its applicability to medicinal use in several human diseases using cell-based assays. As a result, compound 1 attenuated cisplatin-induced nephrotoxicity in LLC-PK1 cells and exhibited a significant inhibitory effect on angiogenesis in HUVECs. These results collectively reflect the beneficial effects of compound 1 in cancer treatment.

KEYWORDS:

Angiogenesis; Cerebroside; Hericiaceae; Hericium erinaceus; Nephrotoxicity

PMID:
26547693
DOI:
10.1016/j.bmcl.2015.10.092
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center