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Life Sci. 2015 Dec 15;143:182-6. doi: 10.1016/j.lfs.2015.11.005. Epub 2015 Nov 10.

The benefits of coffee on skeletal muscle.

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School of Pharmacy, Wingate University, 515 N. Main Street, Wingate, NC 28174, United States. Electronic address:


Coffee is consumed worldwide with greater than a billion cups of coffee ingested every day. Epidemiological studies have revealed an association of coffee consumption with reduced incidence of a variety of chronic diseases as well as all-cause mortality. Current research has primarily focused on the effects of coffee or its components on various organ systems such as the cardiovascular system, with relatively little attention on skeletal muscle. Summary of current literature suggests that coffee has beneficial effects on skeletal muscle. Coffee has been shown to induce autophagy, improve insulin sensitivity, stimulate glucose uptake, slow the progression of sarcopenia, and promote the regeneration of injured muscle. Much more research is needed to reveal the full scope of benefits that coffee consumption may exert on skeletal muscle structure and function.


Autophagy; Coffee; Insulin sensitivity; Regeneration; Sarcopenia; Skeletal muscle

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