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Cell. 2015 Nov 5;163(4):811-28. doi: 10.1016/j.cell.2015.10.044.

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.

Author information

1
Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. Electronic address: fxyu@fudan.edu.cn.
2
Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, China.
3
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: kuguan@ucsd.edu.

Abstract

Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status. Dysregulation of the Hippo pathway exerts a significant impact on cancer development. Further investigation of the functions and regulatory mechanisms of this pathway will help uncovering the mystery of organ size control and identify new targets for cancer treatment.

PMID:
26544935
PMCID:
PMC4638384
DOI:
10.1016/j.cell.2015.10.044
[Indexed for MEDLINE]
Free PMC Article
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