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Hum Gene Ther Methods. 2015 Dec;26(6):193-6. doi: 10.1089/hgtb.2015.100. Epub 2015 Nov 6.

Human Myoblast and Mesenchymal Stem Cell Interactions Visualized by Videomicroscopy.

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1 Stem Cell Program, Department Internal Medicine, University of California-Davis , Sacramento, California.
2 Department of Otolaryngology-Head and Neck Surgery, University of California-Davis , Sacramento, California.


Muscle-derived progenitor cell (myoblast) therapy has promise for the treatment of denervated, weakened, and fibrotic muscle. The best methods for injecting myoblasts to promote fusion and retention have yet to be determined, however. Mesenchymal stem/stromal cells have also been reported to have beneficial effects in restoring damaged tissue, through increasing vascularization and reducing inflammation. The interactions between human primary skeletal myoblasts and bone marrow-derived mesenchymal stem/stromal cells were examined using time-lapse images put into video format. Of interest, there is a high degree of cell-to-cell interaction with microparticles transferring between both cell types, and formation of nanotubules to bridge cytoplasmic contents between the two types of cell. This model provides an in vitro platform for examining mechanisms for cell-to-cell interaction preceding myoblast fusion.

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