Send to

Choose Destination
J Diabetes Investig. 2015 Nov;6(6):734-8. doi: 10.1111/jdi.12337. Epub 2015 Mar 13.

Efficacy of oral glucocorticoid and cyclosporine in a case of rituximab-refractory type B insulin resistance syndrome.

Author information

Division of Diabetes, Endocrinology and Metabolism, Department of Internal Medicine, Shinshu University School of Medicine Matsumoto, Nagano, Japan.


We describe a case of type B insulin resistance syndrome associated with systemic lupus erythematosus (SLE) that was refractory to rituximab and successfully treated with a combination of oral glucocorticoids and cyclosporine. Prior to treatment, insulin resistance was severe, and application of a hyperinsulinemic euglycemic clamp was not possible despite the continuous intravenous infusion of insulin at a maximum rate of 9.0 mU/kg/min. The addition of cyclosporine to oral glucocorticoid therapy resulted in remission of insulin resistance. The combination of oral prednisolone and cyclosporine might be effective in treating type B insulin resistance syndrome, particularly in rituximab-resistant cases. However, nephrotoxicity is a particular concern for patients receiving long-term cyclosporine therapy.


Cyclosporine; Systemic lupus erythematosus; Type B insulin resistance syndrome

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center