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Curr Ther Res Clin Exp. 2015 May 27;77:73-8. doi: 10.1016/j.curtheres.2015.05.001. eCollection 2015 Dec.

Use of Arctium lappa Extract Against Acetaminophen-Induced Hepatotoxicity in Rats.

Author information

1
Deanship of Scientific Research, King Khalid University, Abha, Saudi Arabia ; Department of Zoology, Damanhour University, Damanhour, Egypt.
2
Department of Biology, Princess Nora Bint Abdul Rahman University, Riyadh, Saudi Arabia.

Abstract

BACKGROUND:

Severe destructive hepatic injuries can be induced by acetaminophen overdose and may lead to acute hepatic failure.

OBJECTIVE:

To investigate the ameliorative effects of Arctium lappa root extract on acetaminophen-induced hepatotoxicity.

METHODS:

Rats were divided into 4 groups: normal control group, Arctium lappa extract group, acetaminophen-injected group, and acetaminophen treated with Arctium lappa extract group.

RESULTS:

The treatment with Arctium lappa extract reduced serum alanine transaminase, aspartate aminotransferase, and alkaline phosphatase in the acetaminophen group when compared with the control group. DNA fragments in the acetaminophen-injected group were also significantly increased (P < 0.05). The comet assay revealed increased detaching tail length and DNA concentration during the hepatic toxicity in the acetaminophen group. The malondialdehyde content was inhibited by Arctium lappa treatment (12.97±0.89 nmol/mg) when compared with the acetaminophen-treated-only group (12.97±0.89 nmol/mg). Histopathologic examination revealed that acetaminophen administration produced hepatic cell necrosis, infiltrate of lymphocytes, and vacuolation that were associated with the acetaminophen-treated animal group, but the degree of acetaminophen-induced hepatotoxicity was mediated by treatment with Arctium lappa extract.

CONCLUSIONS:

Arctium lappa can prevent most of the hepatic tissue damage caused by acetaminophen overdose in rats.

KEYWORDS:

Arctium lappa; acetaminophen; comet assay; hepatotoxicity; lipid peroxidation

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