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Cell Mol Life Sci. 2015 Dec;72(24):4825-48. doi: 10.1007/s00018-015-2044-6. Epub 2015 Nov 5.

Neuronal correlates of depression.

Author information

1
Division of Science, Experimental Research Building, Office 106, New York University Abu Dhabi (NYUAD), Saadiyat Island Campus, P.O. Box 129188, Abu Dhabi, United Arab Emirates. dc151@nyu.edu.
2
Division of Science, Experimental Research Building, Office 106, New York University Abu Dhabi (NYUAD), Saadiyat Island Campus, P.O. Box 129188, Abu Dhabi, United Arab Emirates.
3
Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ming-hu.han@mssm.edu.
4
Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ming-hu.han@mssm.edu.

Abstract

Major depressive disorder (MDD) is a common psychiatric disorder effecting approximately 121 million people worldwide and recent reports from the World Health Organization (WHO) suggest that it will be the leading contributor to the global burden of diseases. At present, the most commonly used treatment strategies are still based on the monoamine hypothesis that has been the predominant theory in the last 60 years. Clinical observations show that only a subset of depressed patients exhibits full remission when treated with classical monoamine-based antidepressants together with the fact that patients exhibit multiple symptoms suggest that the pathophysiology leading to mood disorders may differ between patients. Accumulating evidence indicates that depression is a neural circuit disorder and that onset of depression may be located at different regions of the brain involving different transmitter systems and molecular mechanisms. This review synthesises findings from rodent studies from which emerges a role for different, yet interconnected, molecular systems and associated neural circuits to the aetiology of depression.

KEYWORDS:

Circadian rhythm; Depression; Epigenetics; Homeostasis; Immune; Molecular signalling; Neural circuit; Neurogenesis; Sleep deprivation

PMID:
26542802
PMCID:
PMC4709015
DOI:
10.1007/s00018-015-2044-6
[Indexed for MEDLINE]
Free PMC Article

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