Targeting melanoma: unusual epigenetics reveals the dynamic rewiring of metastatic cells

Epigenomics. 2015 Oct;7(7):1079-81. doi: 10.2217/epi.15.67. Epub 2015 Nov 6.
No abstract available

Keywords: DNA hypomethylation; TBC1D16; cryptic promoter; drug sensitivity; melanoma biomarker.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • DNA Methylation / drug effects
  • Epigenesis, Genetic
  • GTPase-Activating Proteins / antagonists & inhibitors
  • GTPase-Activating Proteins / genetics
  • GTPase-Activating Proteins / metabolism
  • Humans
  • Melanoma / drug therapy*
  • Melanoma / genetics
  • Melanoma / pathology
  • Molecular Targeted Therapy*
  • Promoter Regions, Genetic
  • Protein Kinase Inhibitors / therapeutic use*
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors
  • Proto-Oncogene Proteins B-raf / genetics
  • Proto-Oncogene Proteins B-raf / metabolism
  • Recurrence
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / genetics
  • Skin Neoplasms / pathology

Substances

  • Antineoplastic Agents
  • GTPase-Activating Proteins
  • Protein Kinase Inhibitors
  • TBC1D16 protein, human
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf