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J Womens Health (Larchmt). 2015 Dec;24(12):1021-9. doi: 10.1089/jwh.2015.5358. Epub 2015 Nov 5.

Defining Vitamin D Deficiency and Its Relationship to Hypertension in Postmenopausal Korean Women.

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1 Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University Guri Hospital , Guri, Korea.
2 Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University Medical Center , Seoul, Korea.



Inconsistent results regarding the association between low vitamin D level and hypertension (HTN) have led to uncertainty in clinical practice as to the use of vitamin D cutoff value. The aims of this study were to investigate the association between vitamin D deficiency and HTN in postmenopausal women and to determine the clinically significant cutoff value for vitamin D deficiency.


We analyzed data from the Korean National Health and Nutrition Examination Survey 5 database (4107 postmenopausal women, aged 50-79 years). The cutoff value for vitamin D deficiency was based on the changes in parathyroid hormone (PTH) level according to serum 25(OH)D value.


PTH levels were significantly higher in groups with serum 25(OH)D <15 ng/mL (p < 0.001). When a serum 25(OH)D value of 15 ng/mL was used as a cutoff value, 35.2% of the subjects were found to be vitamin D deficient. Although the association between 25(OH)D level <15 ng/mL and systolic blood pressure did not remain significant after adjusting for season (p = 0.30), multiple logistic regression analysis revealed that 25(OH)D level <15 ng/mL was an independent risk factor for HTN (adjusted odds ratio [OR] 1.285, 95% confidence interval [CI] 1.024-1.614, p = 0.031).


Using serum PTH level, we defined vitamin D deficiency as 25(OH)D <15 ng/mL in postmenopausal women. Vitamin D deficiency [25(OH)D <15 ng/mL] was a significant risk factor for HTN in postmenopausal women.

[Indexed for MEDLINE]

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