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Aging (Albany NY). 2015 Oct;7(10):754-65.

Systemic Problems: A perspective on stem cell aging and rejuvenation.

Author information

1
Department of Bioengineering, UC Berkeley; QB3, CA 94709, USA.

Abstract

This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are "beyond parabiosis" for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging.

KEYWORDS:

aging; neurogenesis; parabiosis; rejuvenation; stem cells

PMID:
26540176
PMCID:
PMC4637204
DOI:
10.18632/aging.100819
[Indexed for MEDLINE]
Free PMC Article

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