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Discoveries (Craiova). 2014 Apr-Jun;2(2):e15.

New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond.

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Department of Biology, University of Texas- Pan American, 1201 W. University Dr., Edinburg, TX 78539, USA.
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave HCSM 6-117, New York, NY 10029, USA.


The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduction, cancer, aging and metabolism. Elucidating the signaling pathways that are impacted by NFIL3 and the regulatory mechanisms that it targets, inhibits or activates will be critical for developing a clearer picture of its physiological roles in disease and normal processes. This review will discuss the recent advances and emerging issues regarding NFIL3-mediated transcriptional regulation of CEBPβ and FOXO1 activated genes and signal transduction.


CEBPβ; Cancer; Immunology; Metabolism; NFIL3

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