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Cancer. 2016 Feb 1;122(3):456-63. doi: 10.1002/cncr.29770. Epub 2015 Nov 4.

Outreach invitations for FIT and colonoscopy improve colorectal cancer screening rates: A randomized controlled trial in a safety-net health system.

Author information

1
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
2
Parkland Health and Hospital System, Dallas, Texas.
3
Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas.
4
Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.
5
Veterans Affairs San Diego Health Care System, San Diego, California.
6
Division of Gastroenterology, Department of Internal Medicine, Moores Cancer Center, University of California at San Diego, La Jolla, California.

Abstract

BACKGROUND:

The effectiveness of colorectal cancer (CRC) screening is limited by underuse, particularly among underserved populations. Among a racially diverse and socioeconomically disadvantaged cohort of patients, the authors compared the effectiveness of fecal immunochemical test (FIT) outreach and colonoscopy outreach to increase screening participation rates, compared with usual visit-based care.

METHODS:

Patients aged 50 to 64 years who were not up-to-date with CRC screening but used primary care services in a large safety-net health system were randomly assigned to mailed FIT outreach (2400 patients), mailed colonoscopy outreach (2400 patients), or usual care with opportunistic visit-based screening (1199 patients). Patients who did not respond to outreach invitations within 2 weeks received follow-up telephone reminders. The primary outcome was CRC screening completion within 12 months after randomization.

RESULTS:

Baseline patient characteristics across the 3 groups were similar. Using intention-to-screen analysis, screening participation rates were higher for FIT outreach (58.8%) and colonoscopy outreach (42.4%) than usual care (29.6%) (P <.001 for both). Screening participation with FIT outreach was higher than that for colonoscopy outreach (P <.001). Among responders, FIT outreach had a higher percentage of patients who responded before reminders (59.0% vs 29.7%; P <.001). Nearly one-half of patients in the colonoscopy outreach group crossed over to complete FIT via usual care, whereas <5% of patients in the FIT outreach group underwent usual-care colonoscopy.

CONCLUSIONS:

Mailed outreach invitations appear to significantly increase CRC screening rates among underserved populations. In the current study, FIT-based outreach was found to be more effective than colonoscopy-based outreach to increase 1-time screening participation. Studies with longer follow-up are needed to compare the effectiveness of outreach strategies for promoting completion of the entire screening process.

KEYWORDS:

colonoscopy; colorectal cancer screening; fecal immunochemical test; navigation; randomized controlled trial; safety-net health system

PMID:
26535565
PMCID:
PMC4724227
DOI:
10.1002/cncr.29770
[Indexed for MEDLINE]
Free PMC Article

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