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J Exerc Rehabil. 2015 Oct 30;11(5):244-50. doi: 10.12965/jer.150237. eCollection 2015 Oct.

Role of creatine supplementation in exercise-induced muscle damage: A mini review.

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College of Physical Education, Kookmin University, Seoul, Korea.
Department of Football Management, Munkyung College, Mungyeong, Korea.
Division of Sport Science, Konkuk University, Choongju, Korea.


Muscle damage is induced by both high-intensity resistance and endurance exercise. Creatine is a widely used dietary supplement to improve exercise performance by reducing exercise-induced muscle damage. Many researchers have suggested that taking creatine reduces muscle damage by decreasing the inflammatory response and oxidative stress, regulating calcium homeostasis, and activating satellite cells. However, the underlying mechanisms of creatine and muscle damage have not been clarified. Therefore, this review discusses the regulatory effects of creatine on muscle damage by compiling the information collected from basic science and sports science research.


Creatine; Dietary supplement; Exercise-induced muscle damage

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