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J Biol Chem. 2016 Jan 1;291(1):1-10. doi: 10.1074/jbc.R115.693903. Epub 2015 Nov 3.

Immunometabolism: Cellular Metabolism Turns Immune Regulator.

Author information

1
From the School of Biochemistry and Immunology and.
2
From the School of Biochemistry and Immunology and School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland finlayd@tcd.ie.

Abstract

Immune cells are highly dynamic in terms of their growth, proliferation, and effector functions as they respond to immunological challenges. Different immune cells can adopt distinct metabolic configurations that allow the cell to balance its requirements for energy, molecular biosynthesis, and longevity. However, in addition to facilitating immune cell responses, it is now becoming clear that cellular metabolism has direct roles in regulating immune cell function. This review article describes the distinct metabolic signatures of key immune cells, explains how these metabolic setups facilitate immune function, and discusses the emerging evidence that intracellular metabolism has an integral role in controlling immune responses.

KEYWORDS:

dendritic cell; glycolysis; immunometabolism; inflammatory microenvironment; lymphocyte; macrophage; metabolite; mitochondria; neutrophil; oxidative phosphorylation

PMID:
26534957
PMCID:
PMC4697146
DOI:
10.1074/jbc.R115.693903
[Indexed for MEDLINE]
Free PMC Article

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