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Ann Neurol. 1989 Apr;25(4):404-6.

Multicenter trial of naloxone in Alzheimer's disease.

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1
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.

Abstract

In a double-blind, placebo-controlled, crossover study of intravenously administered naloxone hydrochloride, 54 subjects with clinically ascertained Alzheimer's disease tested at three university centers showed no significant improvement in neuropsychological performance after 1-mg or 10-mg doses; 15 patients at 1 center were similarly unimproved after receiving 30 mg naloxone (single blind). Findings fail to support claims that naloxone monotherapy ameliorates cognitive impairments of Alzheimer's disease.

PMID:
2653175
DOI:
10.1002/ana.410250413
[Indexed for MEDLINE]
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