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J Neuroimmunol. 2015 Nov 15;288:25-33. doi: 10.1016/j.jneuroim.2015.08.020. Epub 2015 Sep 4.

Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais.

Author information

1
Hawai'i Center for AIDS.
2
Department of Tropical Medicine, Medical Microbiology & Pharmacology.
3
SEARCH.
4
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
5
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
6
The Thai Red Cross AIDS Research Center, Bangkok, Thailand.
7
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
8
Biostatistics and Data Management Core, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI, USA.
9
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
#
Contributed equally

Abstract

HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naïve, HIV-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2(+)non-classical monocytes were associated with worse neuropsychological test performance (r=0.43, p=0.024). CCR2(+)non-classical monocyte count inversely correlated with CSF neopterin (r=-0.43, p=0.035) and plasma TNF-α levels (r=-0.40, p=0.041). These data benchmark CCR2(+)non-classical monocytes as an independent index of cognitive impairment.

KEYWORDS:

C-C chemokine receptor (CCR) CCR2; CD163; HIV-associated neurocognitive disorders (HAND); Monocytes; Neopterin

PMID:
26531691
PMCID:
PMC4633708
DOI:
10.1016/j.jneuroim.2015.08.020
[Indexed for MEDLINE]
Free PMC Article

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