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Am J Physiol Endocrinol Metab. 2016 Jan 1;310(1):E1-E14. doi: 10.1152/ajpendo.00429.2015. Epub 2015 Nov 3.

Advances in high-density lipoprotein physiology: surprises, overturns, and promises.

Author information

1
Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
2
Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece kkypreos@med.upatras.gr.

Abstract

Emerging evidence strongly supports that changes in the HDL metabolic pathway, which result in changes in HDL proteome and function, appear to have a causative impact on a number of metabolic disorders. Here, we provide a critical review of the most recent and novel findings correlating HDL properties and functionality with various pathophysiological processes and disease states, such as obesity, type 2 diabetes mellitus, nonalcoholic fatty liver disease, inflammation and sepsis, bone and obstructive pulmonary diseases, and brain disorders.

KEYWORDS:

HDL; bone; brain; disease; inflammation; obesity; obstructive pulmonary; type 2 diabetes mellitus

PMID:
26530157
DOI:
10.1152/ajpendo.00429.2015
[Indexed for MEDLINE]
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